The history of Yeşilyurt is inextricably linked with the rich past of its metropolitan center, the city of Malatya, and the entire region, which for millennia was a cradle of great civilizations. Archaeological finds indicate that these lands were inhabited as early as the 4th-3rd millennia BC. At various times, Hittites, Assyrians, Romans, Byzantines, Seljuks, and Ottomans ruled here, each leaving their mark on the culture and history of this part of Turkey.
Although the exact date of the settlement's founding at the site of modern Yeşilyurt is unknown, the first traces of permanent life in this area date back to the Byzantine era of the 8th–9th centuries. Remnants of an ancient settlement were discovered in the Kaletepe area, and nearby tombs even point to human presence during the Roman period. In the Ottoman era, this area was known as Çırmıktı and was a prosperous village. Truly permanent settlements began to form here around the middle of the 18th century. After the formation of the republic, the town was renamed İsmetpaşa, and in 1957, it received district center status and its current name — Yeşilyurt, which translates as "green homeland."
The development of Yeşilyurt and the entire region was facilitated by its strategic geographical position. For centuries, it sat at the intersection of important trade routes connecting the Black Sea with Mesopotamia, and Anatolia with Iran and the Far East. Another vital factor was the fertility of the land, irrigated by numerous springs, the main one being the Derme spring, which supplies water to all of Malatya. These favorable conditions made the region an important agricultural hub.
During the Ottoman period, the territory of present-day Yeşilyurt was known as the "Aspozan Gardens" and was used primarily as summer residences and gardens for the residents of Malatya. The economy was based on agriculture: cotton and fruits were grown here, and livestock was raised. Early cultural diversity is evidenced by surviving historical buildings, such as old mosques and the Tashhoron Armenian Church, indicating the peaceful coexistence of different communities.