The history of the city of Itaquaquecetuba is closely linked to the colonial past of Brazil and the work of Jesuit missionaries. The settlement was founded between 1560 and 1563 by Jesuits led by Father José de Anchieta. Initially, it was one of twelve villages established for the evangelization of indigenous peoples, specifically the Guayanás and Tupi. On September 8, 1560, a chapel was founded in honor of Our Lady of Help (Nossa Senhora d'Ajuda), which is considered the city's founding date.
The city's name comes from the Tupi language: the word takwakisé-tube means "place of many bamboo, sharp as knives." This refers to the natural features of the area near the Tietê River, which played an important role in the lives of the early settlers. Despite its early founding, the settlement developed very slowly over the centuries and was almost abandoned by the beginning of the 20th century.
The turning point in the city's history came in 1958, when Itaquaquecetuba gained the status of an independent municipality after separating from Mogi das Cruzes. Since then, thanks to the efforts of local authorities, an active process of industrialization began. Its geographical proximity to the São Paulo metropolis contributed to rapid economic and demographic growth, transforming the former village into a major industrial suburb.